here CARMA proteins represent a family of scaffold molecules which play several crucial biological functions, including regulation of immune response and inflammation, tissue homeostasis, and modulation of G-Protein Coupled Receptor (GPCR) signaling.Among the CARMA proteins, CARD14/CARMA2 and its alternatively spliced isoforms are specifically expr
Abstract Historical papers are often locally damaged by exogenous influences and/or have endogenously degraded paper areas.The stabilization of such papers is very important because further use of the object can cause additional damage.Different types of nanocellulose are interesting as a novel stabilizing materials for paper due to their close str
Abstract Recent evidence has indicated that circular RNAs (circRNAs), a novel type of regulatory RNA, play important roles in the development and progression of various cancers.However, the potential regulatory roles and chicago cubs earrings molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain largely unclear.Here, we
Abstract This work introduces a method to tune a sequence-based generative model for molecular de novo design that through augmented episodic likelihood can learn to generate structures with certain specified desirable properties.We demonstrate how this model can execute a range of tasks such as generating analogues to a query structure and generat